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Claudia Fischbach-Teschl

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  • Claudia Fischbach-Teschl
  • Dept: Biomedical Engineering
  • Title: Associate Professor
  • Address: 157 Weill Hall
  • Phone: 607 255-4547
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Biography

Claudia Fischbach-Teschl is an Associate Professor of Biomedical Engineering at Cornell University. She received her Ph.D. in Pharmaceutical Technology from the University of Regensburg, Germany and holds an M.S. in Pharmacy from the Ludwigs-Maximilians-University, Munich, Germany. She conducted her postdoctoral work at Harvard University in the Division of Engineering and Applied Sciences and joined the faculty of Cornell in 2007. Dr. Fischbach-Teschl's lab applies biomedical engineering strategies to study cancer with the ultimate goal of identifying new mechanisms that may ultimately help to prevent and treat this disease. She serves on the NIH Tumor Microenvironment Study Section and is an editorial board member of various journals including the new ACS journal Biomaterials Science and Engineering. studies cells under conditions that do not reflect the microenvironmental context that cells experience in the body. By exploring tissue engineering, microfabrication, and biomaterials strategies the Fischbach-Teschl lab engineers culture models that allow studying tumor cells under conditions that mimic those within patients. In particular, the Fischbach-Teschl lab uses these model systems to gain a better understanding of the biological and physical principles that tumors use to modulate the function of blood vessels, stem cells, and bone metastatic sites, all parameters ultimately contributing to increased cancer aggressiveness and worse clinical prognosis.

Research Interests

Cellular interactions with their surrounding including other cells and extracellular matrix are critically important in the development and progression of cancer. However, current cancer research mostly studies cells under conditions that do not reflect the microenvironmental context that cells experience in the body. By exploring tissue engineering, microfabrication, and biomaterials strategies the Fischbach-Teschl lab engineers culture models that allow studying tumor cells under conditions that mimic those within patients. In particular, the Fischbach-Teschl lab uses these model systems to gain a better understanding of the biological and physical principles that tumors use to modulate the function of blood vessels, stem cells, and bone metastatic sites, all parameters ultimately contributing to increased cancer aggressiveness and worse clinical prognosis.

 

Selected Publications

  • Infanger, DW, Y J. Cho, BS Lopez, S. Mohanan, SC Liu, D. Gursel, JA Boockvar, Claudia Fischbach. 2013. "Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche." Cancer Reseach 73 (23): 7079-89.
  • Lynch , ME, D. Brooks, K. Dent, M. van der Meulen, Claudia Fischbach. 2013. "In Vivo Tibial Compression Decreases Osteolysis and Tumor Formation in a Human Metastatic Breast Cancer Model." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 28 (11): 2357-67.
  • Chandler, E M., Bo Ri Seo, J P. Califano, R C. Eguiluz, J S. Lee, C J. Yoon, D T. Tims, J X. Wang, L. Cheng, S. Mohanan, M R. Buckley, I. Cohen, A Y. Nikitin, R M. Williams, D. Gourdon, C A. Reinhart-King, Claudia Fischbach. 2012. "Implanted adipose progenitor cells as physicochemical regulators of breast cancer." Proc Natl Acad of Sci USA 109 (25): 9786-91.
  • Pathi, S P., D D W. Lin, J R. Dorvee, L A. Estroff, Claudia Fischbach. 2011. "Hydroxyapatite Nanoparticle-containing scaffolds for study of breast cancer bone metastasis." Biomaterials 32 (22): 5112-22.
  • Fischbach, Claudia, R. Chen, T. Matsumoto, T. Schmelzle, J S. Brugge, P J. Polverini, D. J. Mooney. 2007. "Engineering tumors with 3D scaffolds." Nature methods 4 (10): 855-60.

Selected Awards and Honors

  • Emerging Leaders Lecturer (University of Toronto, Department of Chemical Engineering and Applied Chemistry) 2014
  • Humboldt Research Fellowship for Experienced Researchers (Max Planck Institute for Colloids and Interfaces in Potsdam, Germany) 2013
  • Visiting Professor (Julius-Maximilians-Universität Würzburg, Wuerzburg, Germany) 2013
  • Affinito Stewart Award (The President's Council of Cornell Women) 2010
  • ORS Young Investigator (AAOS / ORS Molecular Biology and Therapeutics in Musculoskeletal Oncology (MBTMO) Meeting) 2008

Websites

Education

  • MS (Pharmacy), Ludwig Maximilians University, 1998
  • Ph D (Pharmaceutical Technology), University of Regensburg, 2003