Mandy B. Esch is a CNST project leader in the Nanoscale Imaging and Spectroscopy Group. She received an M.S. in Biology and a Ph.D. in Biotechnology from the Julius Maximilians (Würzburg) University in Germany. During her PhD research she developed paper-microfluidics and microfluidic biosensors for the detection of pathogens that can contaminate drinking water. In 2001, Mandy joined the Cornell Nanoscale Science and Technology Facility as life sciences liaison, where she helped create nanobiotechnology projects. In 2007, she joined the department of Biomedical Engineering at Cornell University as a senior research associate. While there, she developed several patents for multi-organ body-on-a-chip systems. For this work, her team received the 2015 Lush Science Prize. From 2015 to 2016 Mandy spent a year as an assistant professor at Syracuse University at the Department of Biomedical and Chemical Engineering. She taught nanobiotechnology and built a laboratory for tissues-on-chip research. In 2016 Mandy moved to Maryland, where she joined NIST. Her work at NIST will focus on integrating tissue sensors with tissues-on-a-chip devices.
- Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue(link is external), M.B. Esch, H. Ueno, D.R. Applegate, M.L. Shuler, Lab on a Chip, 2016, 16(14), 2719-2729.
- Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs(link is external), C. Oleaga, C. Bernabini, A.S.T. Smith, B. Srinivasan, M. Jackson, W. McLamb, V. Platt, R. Bridges, Y. Cai, N. Santhanam, B. Berry, S. Najjar, N. Akanda, X. Guo, C. Martin, G. Ekman, M. B. Esch, J. Langer, G. Ouedraogo, J. Cotovio, L. Breton, M. L. Shuler, J. J. Hickman, ScientificReports, 2016, 6, 1-17.
- Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow(link is external), M.B. Esch, J.M. Prot, Y.I. Wang, P. Miller, J.R. Llamas-Vidales, B.A. Naughton, D. Applegate, M.L. Shuler, Lab on a Chip, 2015, 15 (10), 2269-2277.
- Endothelial retention and phenotype on carbonized cardiovascular implant surfaces(link is external), C.M. Frendl, S.M. Tucker, N.A. Khan, M.B. Esch, S. Kanduru, T.M. Cao, J. Butcher, Biomaterials, 2014, 35 (27), 7714-7723.
- How multi-organ microdevices can help foster drug development(link is external), M.B. Esch, A.S.T. Smith, J.M. Prot, C. Oleaga, J.J. Hickman, M.L. Shuler, Advanced Drug Delivery Reviews, 2014, 69, 158-169.