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The majority of Prof. Antaki's professional career has been devoted to development of blood-wetted medical devices. His research focuses on the methodology by which these devices are designed and used clinically. His group was one of the pioneers in physiological feedback control of implanted ventricular assist devices, and also developed one of the first decision support programs for identifying heart failure patients who could potentially recover with the acute mechanical circulatory assistance. Over the past 24 years, Antaki has contributed to the development of several heart-assist devices used clinically, including the Heartmate-II, Novacor, Ventracor, TandemHeart, and Levacor. In 1997, he directed a multidisciplinary team that produced the Streamliner heart-assist device - the world's first magnetically levitated rotodynamic blood pump to be tested in-vivo.
The current emphasis of Prof. Antaki's research involves five application areas: circulatory support systems for children, decision-support tools for severe heart failure, diagnostic technology for the home and point-of-care to improve patient engagement, multi-scale modeling of thrombosis in artificial circulation, and development of medical devices for global health. A nascent, overarching project aims to accelerate medical innovation by professional networking between physicians, medical product designers, and patients. Although these interests and experiences are diverse, they share a common theme of improving healthcare though biomedical engineering.
- Antaki, J F., R Wampler. 2012. "The Future of Mechanical Circulatory Support." In Mechanical Circulatory Support: A Companion to Braunwald's Heart Disease , edited by RL Kormos & L Miller , 333-335.
- Antaki, James, M R. Ricci, J E. Verkaik, S T. Snyder, T M. Maul, J. Kim, D. Paden, B E. Paden, H S Borovetz. 2010. "PediaFlow, Maglev Ventricular Assist Device: A Prescriptive Design Approach." Cardiovascular Engineering Technology 1 (1).
- Wu, W T., N. Aubry, M. Massoudi, J. Kim, James Antaki. 2014. "A numerical study of blood flow using mixture theory." International Journal of Engineering Science Volume 76: 56-72.
- Zhao, R., M V. Kameneva, James Antaki. 2007. "Investigation of platelet margination phenomena at elevated shear stress." Biorheology 44 (3): 161-177.
- Loghmanpour, N A., M K. Kanwar, M J. Druzdzel, R L. Benza, S. Murali, James Antaki. 2015. "A new Bayesian network-based risk stratification model for prediction of short-term and long-term LVAD mortality." ASAIO Journal 61 (3): 313-323.
Selected Awards and Honors
- Steven Fenves Award for Systems Research 2009
- August H. Koyanagi Young Investigator Award (11th Congress of the International Society for Rotary Blood Pumps) 2003
- Fellow (American Institute for Medical and Biological Engineering (AIMBE)) 2002
- IEEE Control System Technology Award (shared with BE Paden, UCSB) for development of Streamliner maglev heart assist pump (IEEE) 2001
- Elected one of Pittsburgh Magazine 40 under 40 the top leaders in Pittsburgh under age 40, (Pittsburgh Magazine) 1999
- B.S. (Mechanical Engineering), Rensselaer Polytechnic, 1985
- Ph.D. (Mechanical Engineering), University of Pittsburgh, 1991